Acetyl-CoA Carboxylase 1 (Phospho-Ser79) Rabbit Monoclonal Antibody

Acetyl-CoA carboxylase 1 (ACC1) is a biotin-dependent enzyme that catalyzes the conversion of acetyl-CoA (Item No. 16160) to malonyl-CoA (Item No. 16455), a building block in the biosynthesis of long-chain fatty acids.{60043,60044,60045} It is found at high levels in the liver and adipose tissue and is localized to the cytosol.{60045} Expression of ACC1 is increased by sterol regulatory element binding protein-1a (SREBP-1a) and SREBP-1c, which are induced by insulin, as well as the lipid precursors inositol and choline (Item No. 31178).{60043} ACC1 activity is increased by citrate and inhibited by binding to long-chain acyl-CoAs or by phosphorylation by a number of kinases, including AMPK and TAK1.{60043,60045,60046} Phosphorylation of ACC1 at serine 79 by AMPK inhibits the catalytic activities of ACC1, preventing the generation of malonyl-CoA, whereas dephosphorylation by protein phosphatase 4 promotes hepatic lipogenesis.{59583,59584} Knock-in mice with an alanine in place of serine at position 79 to prevent phosphorylation at this residue of Acc1 have increased de novo lipogenesis, reduced ?-oxidation, and increased insulin resistance and glucose intolerance.{59583} Cayman’s Acetyl-CoA Carboxylase 1 (Phospho-Ser79) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.