Integrin a4/CD49D (C-Term) Rabbit Monoclonal Antibody

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.{59572} The integrin family contains 18 ? subunits and eight ? subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin ?4, also known as CD49D, is a subunit of the ?4?1 and ?4?7 leukocyte-specific integrins, which recognize fibronectin and vascular cell adhesion molecule 1 (VCAM-1) and have essential roles in lymphocyte migration.{59572,59573} Knockout of Itga4, the gene encoding integrin ?4, induces failure of chorioallantoic fusion and is embryonic lethal in mice.{59572} Cayman’s Integrin ?4/CD49D (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.