PTEN (C-Term) Rabbit Monoclonal Antibody

Phosphatase and tensin homolog (PTEN) is a tumor suppressor with roles in cell division, cell migration, and apoptosis.{13065,54452,54453,54454} It is ubiquitously expressed and localized to the cytosol and nucleus where it dephosphorylates phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-(3,4)-diphosphate (PIP2) to antagonize PI3K signaling and regulates spliceosome assembly and pre-mRNA splicing, respectively.{54452} PTEN inhibits cell cycle progression and induces apoptosis, as well as inhibits cell adhesion and migration in vitro.{13040} PTEN deletions have been found in various cancers, including glioblastomas and prostate, breast, and kidney cells. Germline mutations in PTEN induce a variety of syndromes, including Cowden, Bannayan-Riley-Ruvalcaba, Proteus, and Proteus-like syndromes, which are characterized by increased risk of cancers, developmental delays, autism spectrum disorders, and macroencephaly.{54454} Cayman’s PTEN (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.