STAT3a/B (Phospho-Tyr705) Rabbit Monoclonal Antibody

STAT3 is a ubiquitously expressed transcription factor and member of the STAT protein family that has roles in a variety of cellular functions including proliferation, apoptosis, and differentiation, as well as innate and adaptive immunity and stem cell pluripotency.{59562,59553,59872} It contains N-terminal, coiled-coil, DNA binding, and linker domains that mediate nuclear translocation and export, as well as Src homology 2 (SH2) and C-terminal transactivation domains that are subject to phosphorylation.{59554,59560} Alternative splicing of STAT3 pre-mRNA leads to the formation of the full-length isoform STAT3?, as well as STAT3?, a truncated isoform that lacks a portion of the transactivation domain and is considered a dominant-negative regulator of STAT3 transcriptional activation.{59561} STAT3 signaling is inhibited by the negative regulator suppressor of cytokine signaling 3 (SOCS-3) and prevents excessive STAT3 activation.{59553} Phosphorylation of STAT3 at tyrosine 705 (Tyr705) is mediated by JAKs in response to stimulation with cytokines or growth factors and induces STAT3 dimerization and nuclear translocation, leading to STAT3-dependent gene transcription.{59553,59562} Tumor STAT3 (phospho-Tyr705) levels are increased in patients with squamous or renal cell carcinoma and are associated with metastasis.{59563,59564} Cayman's STAT3?/? (Phospho-Tyr705) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.