a-Cardiac Actin (N-Term) Rabbit Monoclonal Antibody

?-Cardiac actin is one of the main actin isoforms found in adult cardiac muscle and the predominant actin in the embryonic heart.{60039,60040} It is a globular protein that forms microfilaments at the Z-disc of sarcomeres and interacts with myosin to perform myofilament, and thus cardiac muscle, contractions.{60041} Knockout of Actc1, the gene encoding ?-cardiac actin, is embryonic lethal in approximately half of mice and generally lethal within two weeks of birth for the other 50%.{60039} Mutations in ACTC1 are associated with atrial septal defects, familial hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy.{60040,60042} Cayman’s ?-Cardiac Actin (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.