Calponin-1 (C-Term) Rabbit Monoclonal Antibody

Calponin-1 is an actin binding protein and a component of smooth muscle cell (SMC) contractile machinery that is encoded by CNN1 in humans.{54434,54435} It is a thin filament-associated protein expressed exclusively in SMCs that interacts with actin to inhibit the movement of actin and myosin, as well as the actin-activated MgATPase activity of phosphorylated myosin.{54436} High levels and low levels of calponin-1 are associated with low and high disease progression risk, respectively, in patients with ductal carcinoma in situ (DCIS).{54437} Downregulation of arterial Cnn1 expression promotes proliferation of vascular SMCs (VSMCs) in DOCA-salt hypertensive rats and a pig model of hypertension induced by aortic coarctation.{54435} Cayman's Calponin-1 (C-Term) Rabbit Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications.