E-Cadherin Rabbit Monoclonal Antibody

E-cadherin is a calcium-dependent adhesion molecule that mediates the formation of adherens junctions and regulates epithelial cell integrity and tissue formation.{57323,57324} It is a transmembrane glycoprotein composed of an extracellular cadherin domain that mediates cell-cell interactions, a transmembrane domain, and a cytoplasmic domain that interacts with a variety of adaptor proteins, including ?-catenin, to influence cytoskeletal dynamics.{57325,57327} E-cadherin is expressed by epithelial cells and localizes to the cell surface, where it assembles into cis-cadherin dimers that subsequently form trans-cadherin dimers with cadherins expressed on adjacent cells, resulting in cell-cell adhesion.{57328} E-cadherin cell surface expression is regulated by clathrin-dependent or -independent endocytosis and drives cytoskeletal rearrangements that are necessary for wound closure.{59539} Loss of E-cadherin is a key feature of the epithelial-to-mesenchymal transition (EMT), a process that promotes tumorigenesis and cancer metastasis.{57323} Cayman’s E-Cadherin Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes E-cadherin at approximately 120 kDa from human samples.