Cyclin D1 Rabbit Monoclonal Antibody

Cyclin D1 is a regulatory protein that controls cell proliferation by promoting cell cycle progression from G1 to S phase.{59540} It is induced during the G1 phase following stimulation with mitogens, including growth factors, hormones, and cytokines, and heterodimerizes with cyclin-dependent kinase 4 (Cdk4) or Cdk6 in the cytoplasm.{59541,59542} The cyclin D1/Cdk4/6 complex translocates to the nucleus and phosphorylates retinoblastoma protein (Rb), permitting expression of E2F transcription factors, which drive S phase entry and progression.{59542,59543,59540} During the G1/S phase transition, cyclin D1 is phosphorylated by glycogen synthase kinase 3? (GSK3?) and exported to the cytoplasm where it is ubiquitinated and degraded. CCND1, the gene encoding cyclin D1, is overexpressed in a variety of human cancers, including mantle cell lymphoma, pancreatic cancer, and breast cancer, and tumor cyclin D1 levels are increased in patients with colorectal cancer and associated with decreased overall survival.{59544,59545} Cayman’s Cyclin D1 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes cyclin D1 at approximately 34 kDa from human samples.