Acetyl-CoA Carboxylase 1 Rabbit Monoclonal Antibody

Acetyl-CoA carboxylase 1 (ACC1) is a biotin-dependent enzyme that catalyzes the conversion of acetyl-CoA (Item No. 16160) to malonyl-CoA (Item No. 16455), a building block in the biosynthesis of long-chain fatty acids.{60043,60044,60045} It is found at high levels in the liver and adipose tissue and is localized to the cytosol.{60045} Expression of ACC1 is increased by sterol regulatory element binding protein-1a (SREBP-1a) and SREBP-1c, which are induced by insulin, as well as the lipid precursors inositol and choline (Item No. 31178).{60043} ACC1 activity is increased by citrate and inhibited by binding to long-chain acyl-CoAs or by phosphorylation by a number of kinases, including AMPK and TAK1.{60043,60045,60046} ACC1 has critical roles in fatty acid synthesis and regulation of insulin levels.{60045} It is involved in numerous pathological conditions, including metabolic diseases such as diabetes and non-alcoholic fatty liver disease (NAFLD), as well as cancer and bacterial infections.{60044} Cayman's Acetyl-CoA Carboxylase 1 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.