Histone H3K79Me3 Monoclonal Antibody

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Trimethylation of histone H3 at lysine 79 (H3K79Me3) is found at promoter regions of both active and silenced genes in human CD4+ T cells and positively correlates with transcriptional repression.{46241} H3K79Me3 is also found at pericentromeric heterochromatin in mouse oocytes and somatic cells.{46242} Levels of H3K79Me3 are decreased in human tumor tissue compared to non-cancerous tissue.{46243} Cayman’s Histone H3K79Me3 Monoclonal Antibody can be used for ELISA, multiplex-based assays, and Western blot (WB) applications.