Ig? Light Chain (human) Rabbit Monoclonal Antibody

Ig? light chain is one type of light chain found in immunoglobulins, which are part of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} Immunoglobulins are produced by B cells and later secreted by plasma cells as antibodies.{55225} They are composed of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} Mammalian immunoglobulins contain either Ig? or Ig? light chains, each of which are composed of a constant and variable domain.{55225,28687} The ratio of Ig? to Ig? light chain-containing antibodies varies between species, with ratios of 20:1, 2:1, and 1:20 in mice, humans, and cattle, respectively. In systemic amyloidosis, a clonal population of plasma cells produces light chains that form amyloid fibrils, and the type of free light chains (FLCs) produced is predominantly Ig? with an Ig? to Ig? ratio of 1:3 or, in amyloidosis patients with nephrotic-range proteinuria, 1:5.{52650} Cayman's Ig? Light Chain (human) Monoclonal Antibody (Clone RM127) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunohistochemistry (IHC) applications. The antibody recognizes the ? light chain from human samples.