Histone H3.3 G34W Rabbit Monoclonal Antibody

Histone H3 is a nuclear protein and component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs). Metazoans have three histone variants: canonical histone H3.1, DNA replication-independent histone H3.3, and the centromeric variant CENP-A.{54380} Histone H3.3 is incorporated into chromatin in a DNA replication-independent manner at sites of active transcription.{54380,54382,54381} Histone H3.3 G34W is a point mutation expressed in giant cell tumors of bone (GCTBs) and is associated with tumor recurrence and metastasis.{61752} Cayman's Histone H3.3 G34W Rabbit Monoclonal Antibody (Clone RM263) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.