GAD65 Monoclonal Antibody
Glutamic acid decarboxylase 65 (GAD65), also known as GAD2, catalyzes the production of GABA from L-glutamic acid and is encoded by GAD2 in humans.{61314} It is primarily expressed in pancreatic islets but is also expressed in neurons of the central and peripheral nervous systems and is localized to vesicular membranes.{61314} Autoantibodies against GAD65 have been found in patients with type 1 diabetes mellitus or gestational diabetes mellitus and have been used as biomarkers of type 1 diabetes mellitus.{61314} GAD65 autoantibodies have also been found in patients with the rare neurological disorder stiff-man syndrome or autoimmune epilepsy.{61315,57555} Cayman’s GAD65 Monoclonal Antibody (Clone 9B10) can be used for ELISA and Western blot (WB) applications. The antibody recognizes GAD65 at 65.4 kDa from human and mouse samples.
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GAD65 Monoclonal Antibody
31360-100
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