Dihydrosanguinarine

Dihydrosanguinarine is an alkaloid and a metabolite of the alkaloid sanguinarine (Item No. 16951) that has diverse biological activities, including anticancer, fungicidal, and antiprotozoal properties.{54383,54384,54385} It inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells when used at concentrations of 10, 20, and 30 µM.{54383} It also reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells. Dihydrosanguinarine inhibits spore germination of the phytopathogenic fungi B. cinerea and E. graminis in vitro (EC50s = 56.35 and 95.75 µg/ml, respectively).{54384} It has protective and curative effects against B. cinerea and E. graminis when applied as a spray to plants either before or after infection, respectively, at concentrations of 100 and 500 µg/ml. Dihydrosanguinarine is also effective against I. multifiliis infestation in S. curriculus (EC50 = 5.18 mg/L) with an LC50 value of 13.3 mg/L.{54385}