Isocurcumenol
Isocurcumenol is a sesquiterpene that has been found in C. zedoaria rhizomes and has diverse biological activities.{60438,60439,60440} It inhibits mycelial growth of the plant pathogenic fungus F. graminearum when used at a concentration of 0.5 mg/ml.{60438} Isocurcumenol is cytotoxic to DLA, A549, KB, and K562 cancer cells (IC50s = 75.3, 75.7, 142.2, and 45.83 µg/ml, respectively).{60439} It inhibits LPS-induced production of nitric oxide (NO) in isolated mouse peritoneal macrophages.{60440} Isocurcumenol (50 mg/kg) reduces LPS/D-galactosamine-induced increases in serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in a mouse model of liver injury.
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