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Anti-SCIMP Monoclonal Antibody (Clone:NVL-07)
30-1506
0,1 mg
€683
Legenda image
Intracellular staining of SCIMP in a population of HEK-293T-SCIMP transfectants using monoclonal antibody (clone NVL-07, purified).The staining pattern reflects heterogeneity in the cell population regarding transfection efficiency.
Product description
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
Specifications
Applications
FC, IP, WB, ICC
Host
Mouse
Clonality
Monoclonal
Clone
NVL-07
Isotype
Mouse IgG2a
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C
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Anti-SCIMP Monoclonal Antibody (Clone:NVL-07)
30-1506
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Anti-SCIMP Monoclonal Antibody (Clone:NVL-07)
30-1506
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