Streptimidone

Streptimidone is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.{52313,52314,52315} It inhibits protein synthesis in a cell-free assay when used at a concentration of 50 ?g/ml.{52314} Streptimidone (20 and 100 ?g/disc) inhibits the growth of S. cerevisiae and the plant pathogenic fungus C. miyabeanus in a disc diffusion assay.{52313} It reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models when administered at doses of 12.5 and 25 mg/kg per day.{52315}