Phospholipase C B2 Polyclonal Antibody

Phospholipase C ?2 (PLC?2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).{59155,59156} It is approximately 135 kDa and is composed of a pleckstrin homology domain, four EF-hand motifs, a catalytic domain, and a C2 domain that are common to all PLCs, as well as a 400-amino acid C-terminal region that is required for PLC?2 activation by the G-protein subunits G?q or G?11.{59157} PLC?2 is also activated by G?? subunits. Upon activation by a G-protein subunit, PLC?2 initiates intracellular signal transduction of extracellular signals using calcium as a cofactor. PLC?2 colocalizes with T1R and T2R taste receptors and Plcb2-/- mice exhibit selective and complete loss of sweet, amino acid, and bitter tastes.{59158} Plcb2-/- mice also exhibit increased coxsackievirus A16-induced pro-inflammatory cytokine production and decreased survival compared with wild-type mice.{59159} Cayman's Phospholipase C ?2 Polyclonal Antibody can be used for immunohistochemistry (IHC) and immunofluorescence (IF) applications.