GABAA Receptor a3 Subunit (N-Term) Polyclonal Antibody

GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: ?1-6, ?1-4, ?1-3, ?, ?, ?, ?, and ?1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by ?1?2?2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The ? subunit of GABAA receptors interfaces with a ? subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the ? subunit. GABAA ?3 subunit expression is decreased in neocortical tissue samples surgically isolated from patients with medically refractory temporal lobe epilepsy.{55213} Knockdown of Gabra3, which encodes the ?3 subunit isoform, prevents stress-induced colonic inflammation in mice.{55216} Cayman’s GABAA Receptor ?3 Subunit (N-Term) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor ?3 subunit at approximately 51 kDa from mouse and rat samples.