Connexin43 Polyclonal Antibody

Connexin43 (Cx43) is a membrane protein and member of the connexin family that is encoded by GJA1 in humans.{55146,55147} It is widely expressed across various tissues, including the heart, brain, and retina, and exhibits plasma membrane localization. Cx43 is a monomeric component of connexons, homo- or heterohexamers that form hydrophilic pores and facilitate the exchange of ions and secondary messengers between the cytoplasm of connected cells at gap junctions. It is essential to cardiomyocyte function and cardiac development, osteoblast and osteocyte survival, and spermatogenesis.{55146} Cx43 is also expressed in various tumor cells, including in the liver, prostate, and breast, and exhibits tumor-specific pro- or anti-metastatic effects.{55146,55148} Inhibition of Gja1 with antisense oligonucleotides promotes wound healing in murine skin, skeletal muscle, cardiac tissue, and vascular endothelium, however, global heterozygous knockdown of Gja1 increases infarct size in a mouse model of ischemia and reperfusion injury.{55146,55147} Levels of Cx43 are decreased in postmortem retinal samples from patients with diabetes compared with control individuals.{55149} Cayman's Connexin43 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes connexin43 at approximately 43 kDa from rat samples.