YTHDF2 Polyclonal Antibody

YTH-Domain family member 2 (YTHDF2) is a reader protein that binds to N6-methyladenosine (m6A) to regulate mRNA degradation.{42713,42714} YTHDF2 binds to m6A sites in the 3'-UTR of mRNA through its C-terminal YTH domain and recruits the CCR4-NOT deadenylase complex via its N-terminus to accelerate mRNA localization to decay sites, such as P-bodies, and promote subsequent degradation.{42713,42714,35631} Ythdf2 knockout results in a build-up of maternal mRNA in oocytes that induces female-specific infertility in mice.{42715} Conditional knockout of Ythdf2 increases the number of hematopoietic stem cells (HSCs) without shifting lineage differentiation or inducing malignancies.{42716} It also increases ex vivo expansion of human umbilical cord HSCs. Cayman's YTHDF2 Polyclonal Antibody can be used for immunofluorescence, immunohistochemistry, and Western blot applications. The antibody recognizes YTHDF2 at 63 kDa from human samples.