GPR99 (C-Term) Polyclonal Antibody
GPR99 is a G protein-coupled receptor (GPCR) that was originally identified as a purinergic receptor, P2Y15.{47265,47266} However, it is activated by leukotriene E4 (LTE4; Item No. 20410) in the low nanomolar range and by ?-ketoglutarate in the high micromolar range.{23197,19519} It is found in the CNS, kidney, epididymis, and other tissues in the mouse, as well as in human kidney, nasal turbinates, and lung, among other tissues.{47267,47268} GPR99 knockout in mice prevents vascular leakage induced by LTE4 and epithelial cell mucin release in mouse nasal mucosa induced by LTE4 or A. alternata.{23197} In the kidney, under acid-base stress, it is involved with the regulation of carbonic acid and sodium chloride resorption through activation by ?-ketoglutarate.{47267} GPR99 is also expressed in mouse retina, and axon growth is increased when it is activated by ?-ketoglutarate in isolated mouse embryo retinal explants.{47269} Cayman’s GPR99 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of GPR99 from human samples.
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GPR99 (C-Term) Polyclonal Antibody
27344-500
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GPR99 (C-Term) Polyclonal Antibody
27344-500
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