6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Productname
6-O-desmethyl Donepezil
27175-1
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Productname
6-O-desmethyl Donepezil
27175-1
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