SRS16-86

SRS16-86 is an inhibitor of ferroptosis.{43387} It inhibits ferroptosis induced by erastin (Item No. 17754) in HT-1080 and NIH3T3 cells when used at a concentration of 1 ?M. SRS16-86 (2 mg/kg) prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1?, TNF-?, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters.{43841} It also increases tissue sparing and improves locomotor recovery in the same model.