B2-Microglobulin Polyclonal Antibody

?2-Microglobulin is a 99-amino acid protein and the light chain component of major histocompatibility complex (MHC) class I molecules.{45065} It is non-covalently associated with the MHC class I ? chain and comprises a protein-building subunit of the MHC class I molecule to facilitate complex transport to the cell surface and antigen presentation to cytotoxic T cells. ?2-Microglobulin is found in cells, as well as in extracellular fluids, including urine and serum, and MHC class I-associated ?2-microglobulin exhibits dissociation and equilibrium exchange with circulating soluble ?2-microglobulin. Serum levels of ?2-microglobulin are increased in patients with renal failure, systemic amyloidosis, various autoimmune diseases, including multiple sclerosis, chronic infections, and a variety of cancers.{45065,45066,45067,45064} It mediates signaling pathways that promote cellular growth, angiogenesis, epithelial-mesenchymal transition (EMT), and bone metastasis and is used as a predictive biomarker of survival in multiple myeloma and colorectal cancers.{45065} Cayman's ?2-Microglobulin Polyclonal Antibody can be used for Western blot and ELISA applications. This antibody recognizes ?2-Microglobulin at ~14 kDa from human samples.