IRF3 Monoclonal Antibody (Clone 1E10)

Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity.{39335,39336,39338,39337,39339} Double-stranded RNA generated during a viral infection leads to IRF3 activation through serine/threonine phosphorylation by TBK1 (Item No. 22817) or IKK? (IKBKE) kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREB binding protein (CREBBP)/p300.{39335,39336,39338,39334} The complex formed by this association, known as DRAF1, activates transcription of interferon ? (IFN-?) and IFN-? as well as other IFN-induced genes, which play a critical role in the type 1 IFN-dependent immune response.{39335,39334,39339} Cayman’s IRF3 Monoclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes IRF3 at ~47 kDa from human samples.