Anti-DNP Polyclonal Antibody

2,4-Dinitrophenol (DNP) is a hapten that induces a strong immune response when attached to proteins or peptides.{48325,48326} DNP can be incorporated at protein carbonyls via covalent linkage of DNP to carbonyl groups using 2,4-dinitrophenylhydrazine (DNPH) or through site-specific incorporation of unnatural amino acids that contain a DNP functional group.{48325,48327} Immunization with DNP-modified proteins or tumor cells induces antibody formation in vivo and has been used in the design of vaccines for clearance of disease-causing cells or viruses and induction of autoimmune diseases such as colitis and thyroiditis.{48328,48329} Cayman’s Anti-DNP Polyclonal Antibody can be used for ELISA, Western blot, and immunoprecipitation applications.