7-oxo Staurosporine

7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites.{41405,41406,41407,41409} It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively).{41406} 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml.{41405} It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin (Item No. 15007; IC50s = 27 and 45 nM, respectively).{41407} 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 ?g/ml).{41408} It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.{41409}