Product description

CD114 / G-CSFR (granulocyte colony-stimulating factor receptor, also known as CSF3R) is a type I transmembrane glycoprotein which upon binding of its ligand (G-CSF, granulocyte colony-stimulating factor) homodimerizes and activates signaling transduction to mediate cell proliferation, survival, and differentiation. It is expressed by granulocytes at all stages of their differentiation, as well as by monocytes, dendritic cells, and mature platelets. Among non-hematopoietic cells, it is expressed e.g. by endothelial cells, placenta, trophoblasts, and many tumor cell lines. This antigen is a target for stem cell mobilization for blood stem cell transplantation, for enhancing recovery of myelopoiesis following chemotherapy and in the treatment of patients with severe chronic neutropenia.

Specifications
Applications
FC
Host
Mouse
Clonality
Monoclonal
Clone
LMM741
Isotype
Mouse IgG1 kappa
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C

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Anti-Hu CD114 PE

1P-157-T100

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Anti-Hu CD114 PE

1P-157-T100

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