Nimbolide
Nimbolide is a terpenoid lactone first isolated from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.{30598} It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3, and PARP.{30598}
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Nimbolide
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