a-Amanitin
?-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.{29206} At 1, 10, and 50 µg/ml, respectively, ?-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.{29205,20588} RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.{29205}
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