Bambuterol (hydrochloride)
Bambuterol is a prodrug form of the ?-adrenergic receptor (?-AR) agonist terbutaline (Item No. 29337).{29051,25395} It is also an inhibitor of butyrylcholinesterase (BChE; IC50 = 3.9 nM for the human enzyme), the enzyme that metabolizes bambuterol into terbutaline, and this inhibition increases the duration of action of terbutaline.{29051,57423} Bambuterol (1 and 2 mg/kg) increases the latency to histamine-induced collapse in guinea pigs.{57422} It completely inhibits ovalbumin-induced decreases in dynamic compliance and increases in pulmonary resistance in ovalbumin-sensitized guinea pigs when administered at a dose of 10 mg/kg. Formulations containing bambuterol have been used in the treatment of asthma.
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