Articaine (hydrochloride)
Most local anesthetics act by abolishing voltage-gated sodium channel currents indiscriminately in all populations of neurons. Articaine is an amide local anesthetic most commonly used in dentistry.{29049} It possesses a unique ester side chain that is metabolized rapidly by circulating esterases.{29050} Articaine is reported to modify cardiac action potentials and ion currents only at concentrations higher than the therapeutic range needed to inhibit voltage-gated sodium channels.{29050}
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