BAY 60-6583
BAY 60-6583 is an adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC50s = >10 µM).{27932} It has been used to decrease superoxide production in neutrophils and to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis in a mouse model of type 2 diabetes and obesity.{27933,27934} BAY 60-6583 has also been examined for potential clinical use in disorders of the coronary arteries and atherosclerosis and in ischemia-reperfusion injury.{27932}
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