Product description

Cariporide is an inhibitor of sodium-hydrogen exchanger 1 (NHE-1; IC50 = 0.56 µM in an intracellular pH recovery assay).{25880} It is selective for NHE-1 over NHE-2 (IC50 = 28 µM in an intracellular pH recovery assay). Cariporide inhibits sodium propionate-induced swelling of isolated human platelets (IC50 = 0.023 µM). It reduces the myocardial infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion when administered at a dose of 1 mg/kg. Cariporide (1 mg/kg) decreases ventricular tachycardia duration in a rat model of coronary artery ligation and reperfusion-induced arrhythmia.{65170}

Specifications
CAS number
159138-80-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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16935-10

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