Doripenem (hydrate)
Doripenem is a broad-spectrum antibiotic in the ?-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.
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