Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf3.{6864,6865,6874} Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.{6874} Caspase-9 is also activated by granzyme B and CPP32.{6864,6865} Activated caspase-9 cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.{6874} Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-?, TRAIL, anti-CD-95, FADD, and TRADD.{6863} Caspase-9 is expressed in a variety of human tissues.{6864,6865}
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Caspase-9 Polyclonal Antibody
160790-1
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Productname
Caspase-9 Polyclonal Antibody
160790-1
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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