FFAR2 (GPR43) (Internal) Polyclonal Antibody

GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate.{25605} GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils.{25606,25605} The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.{25606,25605,25541} Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.