Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).{29439} It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKC?, PKB?, MEK, ERK, c-Raf, c-Src, and c-Abl.{29439} It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.{29439}
Productname
CRT0066101 (hydrochloride)
15337-1
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Productname
CRT0066101 (hydrochloride)
15337-1
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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