BCH

The L-type amino acid transporters (LATs) are Na+-dependent neutral amino acid transporters.{30008} They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43.{30008} LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling.{15559} BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM.{30005,30007} It can inhibit all members of the LAT family at a concentration of 10 mM.{30008} In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.{30008,15559} LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. 13248), through the blood-brain barrier, and this can be inhibited by BCH.{30007,30006}