STING H232 variant; SUMO-tagged (human, recombinant)

STING H232 variant; SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-?B and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The H232 variant of STING is found at a 13.7% frequency in the 1000 Genome Project.{38697} The SNP variant R232 (Item No. 22816) is the most common variant in the human population, found at a frequency of 57.9%. Small ubiquitin-like modifier (SUMO) proteins modify proteins post-translationally, leading to a variety of functional effects.{38902} In unstimulated cells in vitro, sumoylation stabilizes STING, inhibits its degradation, and facilitates oligomerization, leading to increased recruitment and activation of IRF3. In the early phase of herpes simplex virus type 1 (HSV-1) infection in vitro, dimerized STING is sumoylated by Trim38 and then desumoylated by Senp2 and degraded during the late phase of infection.