R-(-)-Deprenyl (hydrochloride)

Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.{23885} R-(?)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 ?M) over MAO-A (Ki = 9.06 ?M).{23886,23884} In addition to finding use against depression, R-(?)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.{15160,23885} The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.{15160}