Resveratrol-3-O-Sulfate (sodium salt)

Resveratrol-3-O-sulfate is a metabolite of resveratrol (Item Nos. 70675 | 10004235).{37575} In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 µM) decreases the expression of IL-1?, IL-1?, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-? and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 µM, and induces apoptosis at concentrations of 25 and 50 µM.{37576} Resveratrol-3-O-sulfate also displaces rosiglitazone (Item No. 71740) from the outer mitochondrial protein mitoNEET (IC50 = 3.36 µM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.{37577}