S18986
S18986 is a positive allosteric modulator of ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices.{33738} S18986 is orally bioavailable and penetrates the blood-brain barrier in animals.{33737} Formulations containing S18986 improve episodic memory in rats.{33737} S18986 is used to elucidate the roles of AMPA receptor signaling in cells and in animals.{33737,33739,33740}
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