CX-516

CX-516 is an AMPA receptor modulator.{39729,39730} It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner.{39730} It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats.{39731} CX-516 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.{39732}