Product description

Tissue transglutaminase (TGM2) post-translationally modifies proteins by catalyzing intermolecular cross-linkages between glutamine and lysine side chains.{30036} TGM2 has roles in neurodegenerative disorders, celiac sprue, cancer, and fibrotic diseases.{30036,30033} Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.{30037} It is orally available and is neuroprotective in mouse models of Huntington’s disease.{30034,30032} Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.{30035}

Specifications
CAS number
56-17-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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Cystamine (hydrochloride)

14882-100

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Cystamine (hydrochloride)

14882-100

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