KT195

The serine hydrolase known as ?/?-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG; Item No. 62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGL?.{30430,30418} While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGL?.{30430} By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells.{30430} KT195 is also reported to reduce IL-1? secretion from lipopolysaccharide-treated macrophages.{30430}