Vildagliptin
Vildagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.003 µM).{24377} It is selective for DPP-4 over DPP-2, DPP-8, and DPP-9 (Kis = >500, 0.81, and 0.095 µM, respectively). Vildagliptin (3 mg/kg) decreases plasma glucose levels and increases plasma insulin levels during an oral glucose challenge in Zucker fa/fa rats.{24378} It prevents increases in liver triglyceride and thiobarbituric acid reactive substance (TBARS) levels in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a high-cholesterol diet.{58931} Formulations containing vildagliptin have been used in the treatment of type 2 diabetes.
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