UNC1999
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer.{18930} UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other histone methytranferases.{25004} UNC1999 has been shown to inhibit H3K27 methylation in MCF10A cells with an IC50 value of 124 nM.{25004} For more information on UNC1999 please visit the Structural Genomics Consortium (SGC). The negative control, UNC2400, for UNC1999 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
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