PJ-34 (hydrochloride)
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} PJ-34 is an inhibitor of PARPs which can be used in cells or in animals.{22593,22588,22592} It binds and inhibits the PARP tankyrase1 (IC50 = 1 ?M).{22590} PJ-34 also inhibits matrix metalloproteinase-2 when used at higher concentrations (IC50 = 56 ?M).{20001}
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